000			05020nam a22005175i 4500
001			978-0-387-69805-2
003			DE-He213
005			20250710084010.0
007			cr nn 008mamaa
008			111207s2012 xxu| s |||| 0|eng d
020			_a9780387698052 _a99780387698052
024	7		_a10.1007/978-0-387-69805-2 _2doi
082	0	4	_a614.5999 _223
100	1		_aGreen, Jeffrey E. _eeditor.
245	1	0	_aGenetically Engineered Mice for Cancer Research _h[recurso electrónico] : _bdesign, analysis, pathways, validation and pre-clinical testing / _cedited by Jeffrey E. Green, Thomas Ried.
264		1	_aNew York, NY : _bSpringer New York, _c2012.
300			_aXX, 632 p. 75 illus., 47 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Preface -- Overview of Designing Genetically-Engineered Mouse Models -- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer -- Using Recombineering Technology To Create Genetically Engineered Mouse Models -- Insertional Mutagenesis for Generating Mouse Models of Cancer -- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer -- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat -- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology -- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry -- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying Mammary Epithelial Stem and Progenitor Cells -- Differentiation Programs in Development and Cancer -- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse -- Mouse Models for Colorectal Cancer -- Src family tyrosine kinases: Implications for mammary tumor progression -- Maspin and Suppression of Tumor Metastasis -- Epigenetic Mouse Models -- Modeling Transforming Growth Factor-ß Signaling in Cancer -- Modeling Stromal-Epithelial Interactions.-  Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.-  Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models -- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models -- Animal Models for Breast Cancer Prevention Resarch -- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies -- Mouse Models in Preclinical Drug Development- Applications to CNS Models -- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine -- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development -- Index.  .
520			_aTechnological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aHUMAN GENETICS.
650		0	_aMEDICAL LABORATORIES.
650		0	_aMICROBIOLOGY.
650		0	_aMEDICAL PARASITOLOGY.
650		0	_aBIOCHEMISTRY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aLABORATORY MEDICINE.
650	2	4	_aMEDICAL MICROBIOLOGY.
650	2	4	_aANIMAL BIOCHEMISTRY.
650	2	4	_aPARASITOLOGY.
700	1		_aRied, Thomas. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387698038
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-69805-2 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c58135 _d58135