000			03525nam a22004335i 4500
001			978-0-387-70630-6
003			DE-He213
005			20250710084010.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387706306 _a99780387706306
024	7		_a10.1007/978-0-387-70630-6 _2doi
082	0	4	_a571.6 _223
100	1		_aWu, Hao. _eeditor.
245	1	0	_aTNF Receptor Associated Factors (TRAFs) _h[recurso electrónico] / _cedited by Hao Wu.
264		1	_aNew York, NY : _bSpringer New York, _c2007.
300			_aXIX, 206 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v597
505	0		_aPhylogeny of the TRAF/MATH Domain -- TRAF1 and Its Biological Functions -- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5 -- TRAF3 and Its Biological Function -- TRAF4, the Unique Family Member -- Characteristics and Biological Functions of TRAF6 -- Ubiquitination and TRAF signaling -- Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway -- Protein-Protein Interactions in TRAF3 -- Molecular Basis for the Unique Specificity of TRAF6 -- TRAF Proteins in CD40 Signaling -- TRAFs in RANK Signaling -- The LT?R Signaling Pathway -- LMP1 TRAFficking Activates Growth and Survival pathways -- Targeting TRAFs for Therapeutic Intervention.
520			_aIt has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.
650		0	_aLIFE SCIENCES.
650		0	_aCYTOLOGY.
650		0	_aDEVELOPMENTAL BIOLOGY.
650	1	4	_aLIFE SCIENCES.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aDEVELOPMENTAL BIOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387706290
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v597
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-70630-6 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c58154 _d58154