000			03324nam a22004815i 4500
001			978-0-387-74039-3
003			DE-He213
005			20250710084019.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387740393 _a99780387740393
024	7		_a10.1007/978-0-387-74039-3 _2doi
082	0	4	_a614.5999 _223
100	1		_aYu, Dihua. _eeditor.
245	1	0	_aBreast Cancer Chemosensitivity _h[recurso electrónico] / _cedited by Dihua Yu, Mien-Chie Hung.
264		1	_aNew York, NY : _bSpringer New York, _c2007.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v608
505	0		_aOverview of Resistance to Systemic Therapy in Patients with Breast Cancer -- Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance -- Therapy-Induced Apoptosis in Primary Tumors -- Cell Cycle Deregulation in Breast Cancer: Insurmountable Chemoresistance or Achilles' Heel? -- p53, BRCA1 and Breast Cancer Chemoresistance -- Integrin-Mediated Adhesion: Tipping the Balance between Chemosensitivity and Chemoresistance -- Insulin-Like Growth Factors and Breast Cancer Therapy -- EGF Receptor in Breast Cancer Chemoresistance -- Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance -- Estrogen Receptors in Resistance to Hormone Therapy -- Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story.
520			_aIn Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aBIOCHEMISTRY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aCELL BIOLOGY.
700	1		_aHung, Mien-Chie. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387740379
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v608
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-74039-3 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c58550 _d58550