000			03452nam a22005055i 4500
001			978-0-387-75613-4
003			DE-He213
005			20250710084022.0
007			cr nn 008mamaa
008			131123s2014 xxu| s |||| 0|eng d
020			_a9780387756134 _a99780387756134
024	7		_a10.1007/978-0-387-75613-4 _2doi
082	0	4	_a616.9 _223
100	1		_aVinks, Alexander A. _eeditor.
245	1	0	_aFundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics _h[recurso electrónico] / _cedited by Alexander A. Vinks, Hartmut Derendorf, Johan W. Mouton.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aIX, 466 p. 110 illus., 12 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Section I: Basic Concepts and Principles -- Introduction to Pharmacodynamics and micrbiology -- In vitro and animal PK/PD model -- MIC and breakpoints -- Principles of applied PK/PD modeling -- Population Pk/PD modeling and its applications to antimicrobials -- Drug resistance and Drug-drug combinations -- Section II: Clinical -- Aminoglycosides -- Beta-lactam antibiotics including continuous infusion -- Macrolides -- Glycopeptides -- Quinolones -- Other.-      .
520			_aOver the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics  is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.
650		0	_aMEDICINE.
650		0	_aIMMUNOLOGY.
650		0	_aMICROBIOLOGY.
650		0	_aTOXICOLOGY.
650		0	_aPUBLIC HEALTH.
650		0	_aEMERGING INFECTIOUS DISEASES.
650	1	4	_aMEDICINE & PUBLIC HEALTH.
650	2	4	_aINFECTIOUS DISEASES.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aMEDICAL MICROBIOLOGY.
650	2	4	_aPUBLIC HEALTH.
700	1		_aDerendorf, Hartmut. _eeditor.
700	1		_aMouton, Johan W. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387756127
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-75613-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SME
942			_2ddc _cER
999			_c58708 _d58708