000			03330nam a22004215i 4500
001			978-0-387-77570-8
003			DE-He213
005			20251006084415.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9780387775708
020			_a99780387775708
024	7		_a10.1007/978-0-387-77570-8 _2doi
082	0	4	_a616.96 _223
100	1		_aMajumder, Hemanta K. _eeditor.
245	1	0	_aDrug Targets in Kinetoplastid Parasites _h[electronic resource] / _cedited by Hemanta K. Majumder.
264		1	_aNew York, NY : _bSpringer New York, _c2008.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances In Experimental Medicine And Biology, _x0065-2598 ; _v625
505	0		_aArsenite Resistance in Leishmania and Possible Drug Targets -- Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids -- Drugs and Transporters in Kinetoplastid Protozoa -- Selective Lead Compounds against Kinetoplastid Tubulin -- Fishing for Anti-Leishmania Drugs: Principles and Problems -- Sterol 14-Demethylase Inhibitors for Trypanosoma cruzi Infections -- Histone Deacetylases -- Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy -- DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy -- Antiparasitic Chemotherapy: -- Searching the Tritryp Genomes for Drug Targets -- Purine and Pyrimidine Metabolism in Leishmania.
520			_aIf viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas' disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.
650		0	_aMEDICINE.
650		0	_aMEDICAL PARASITOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aPARASITOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387775692
830		0	_aAdvances In Experimental Medicine And Biology, _x0065-2598 ; _v625
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-77570-8 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c58984 _d58984