000			03019nam a22005055i 4500
001			978-0-387-84835-8
003			DE-He213
005			20251006084423.0
007			cr nn 008mamaa
008			100715s2009 xxu| s |||| 0|eng d
020			_a9780387848358
020			_a99780387848358
024	7		_a10.1007/978-0-387-84835-8 _2doi
082	0	4	_a614.5999 _223
100	1		_aCostello, Leslie. _eeditor.
245	1	0	_aMitochondria and Cancer _h[electronic resource] / _cedited by Leslie Costello, Keshav Singh.
264		1	_aNew York, NY : _bSpringer New York, _c2009.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aMitochondria and Cancer -- Warburg and his Legacy -- The Lipogenic Switch in Cancer -- Citrate Metabolism in Prostate and Other Cancers -- Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism -- Mitochondrial Respiration and Differentiation -- Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells -- Energy Generating Pathways and the Tumor Suppressor p53 -- Mitochondrial Tumor Suppressors -- Mitochondria in Hematology -- Mitochondria and Oncocytomas -- Mitochondria as Targets for Cancer Therapy -- Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy -- Mitochondrial Nanotechnology for Cancer Therapy.
520			_aNearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aMEDICAL LABORATORIES.
650		0	_aMICROBIOLOGY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aMEDICAL MICROBIOLOGY.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aBIOMEDICINE GENERAL.
650	2	4	_aLABORATORY MEDICINE.
700	1		_aSingh, Keshav. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387848341
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-84835-8 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c59222 _d59222