| 000 | 02740nam a22004335i 4500 | ||
|---|---|---|---|
| 001 | 978-0-387-84847-1 | ||
| 003 | DE-He213 | ||
| 005 | 20251006084423.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2008 xxu| s |||| 0|eng d | ||
| 020 | _a9780387848471 | ||
| 020 | _a99780387848471 | ||
| 024 | 7 |
_a10.1007/978-0-387-84847-1 _2doi |
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| 082 | 0 | 4 |
_a610 _223 |
| 100 | 1 |
_aLaing, Nigel G. _eeditor. |
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| 245 | 1 | 4 |
_aThe Sarcomere and Skeletal Muscle Disease _h[electronic resource] / _cedited by Nigel G. Laing. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York, _c2008. |
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| 300 |
_aXXII, 228 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v642 |
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| 505 | 0 | _aThe Sarcomere and Sarcomerogenesis -- Skeletal Muscle Alpha-Actin Diseases -- Nebulin-A Giant Chameleon -- Skeletal Muscle Disease Due to Mutations in Tropomyosin, Troponin and Cofilin -- Investigations into the Pathobiology of Thin-Filament Myopathies -- Mouse Models for Thin Filament Disease -- Thick Filament Diseases -- Acute Quadriplegic Myopathy: An Acquired "Myosinopathy" -- Third Filament Diseases -- The Z-Disk Diseases -- Intermediate Filament Diseases: Desminopathy -- Muscular Integrity-A Matter of Interlinking Distinct Structures via Plectin -- The Sarcomere and the Nucleus: Functional Links to Hypertrophy, Atrophy and Sarcopenia -- Other Model Organisms for Sarcomeric Muscle Diseases -- Therapeutic Approaches for the Sarcomeric Protein Diseases. | |
| 520 | _aAlthough best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options. | ||
| 650 | 0 | _aMEDICINE. | |
| 650 | 0 | _aHUMAN PHYSIOLOGY. | |
| 650 | 1 | 4 | _aBIOMEDICINE. |
| 650 | 2 | 4 | _aBIOMEDICINE GENERAL. |
| 650 | 2 | 4 | _aHUMAN PHYSIOLOGY. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9780387848464 |
| 830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v642 |
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| 856 | 4 | 0 |
_uhttp://dx.doi.org/10.1007/978-0-387-84847-1 _zVer el texto completo en las instalaciones del CICY |
| 912 | _aZDB-2-SBL | ||
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_2ddc _cER |
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_c59228 _d59228 |
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