000			03705nam a22004095i 4500
001			978-0-387-85766-4
003			DE-He213
005			20251006084426.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9780387857664
020			_a99780387857664
024	7		_a10.1007/978-0-387-85766-4 _2doi
082	0	4	_a610 _223
100	1		_aGunning, Peter. _eeditor.
245	1	0	_aTropomyosin _h[electronic resource] / _cedited by Peter Gunning.
264		1	_aNew York, NY : _bSpringer New York, _c2008.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v644
505	0		_aand Historical Perspective -- and Historical Perspective -- Genes and Their Expression -- Structure and Evolution of Tropomyosin Genes -- Tropomyosin Exons as Models for Alternative Splicing -- Tropomyosin Gene Expression in Vivo and in Vitro -- Protein Structure -- Tropomyosin: Function Follows Structure -- Dimerization of Tropomyosins -- Role in Muscle Function -- Cooperative Binding of Tropomyosin to Actin -- Tropomyosin and the Steric Mechanism of Muscle Regulation -- Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle -- Tropomyosin in Human Disease -- Tropomyosin as a Regulator of Cancer Cell Transformation -- The Role of Tropomyosin in Heart Disease -- Tropomyosins in Skeletal Muscle Diseases -- Tropomyosins in Human Diseases: Ulcerative Colitis -- Tropomyosin Directed Regulation of the Cytoskeleton -- Tropomyosin Function in Yeast -- Isoform Sorting of Tropomyosins -- Human Tropomyosin Isoforms in the Regulation of Cytoskeleton Functions -- Mechanisms of Tropomyosin Function -- Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments -- Tropomyosin and ADF/Cofilin as Collaborators and Competitors -- Caldesmon and the Regulation of Cytoskeletal Functions -- Tropomyosins as Discriminators of Myosin Function -- Tropomodulin/Tropomyosin Interactions Regulate Actin Pointed End Dynamics -- Conclusion -- Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology.
520			_aTropomyosin is one of the two core components of the actin filament and is involved in regulating most if not all functions of these filaments. Tropomyosin has brought together research leaders in this field to review not only what we know but also what the future holds for this field of research. All aspects of tropomyosin biology are covered from gene structure and expression to protein structure, their role in cell function and disease and finally to mechanisms of their function. The book is essential reading for anyone interested in cell structure and function. The actin architectural system is involved in the majority of cellular processes and this book explains how the tropomyosins contribute to this diversity of function. It is not only a comprehensive resource for those working in the field but is also designed to introduce the broader research community to these important molecules.
650		0	_aMEDICINE.
650	1	4	_aBIOMEDICINE.
650	2	4	_aBIOMEDICINE GENERAL.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387857657
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v644
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-85766-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c59289 _d59289