000			04121nam a22004575i 4500
001			978-0-387-88611-4
003			DE-He213
005			20251006084428.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387886114
020			_a99780387886114
024	7		_a10.1007/978-0-387-88611-4 _2doi
082	0	4	_a614.5999 _223
100	1		_aSalter, Russell D. _eeditor.
245	1	0	_aDendritic Cells in Cancer _h[electronic resource] / _cedited by Russell D. Salter, Michael R. Shurin.
264		1	_aNew York, NY : _bSpringer US, _c2009.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aALTERATIONS OF THE DENDRITIC CELL SYSTEM IN CANCER -- The Central Role of Dendritic Cells in Immunity -- Dendritic Cells in Cancer: Emergenceof the Discipline -- Tumor-Infiltrating Dendritic Cells: The Pathologist's Perspective -- Functional Defects of Dendritic Cells in Cancer -- General Properties of Dendritic Cell Populations in Cancer -- Elimination of Dendritic Cells in Cancer -- Mechanisms of Dendritic Cell Dysfunction in Cancer -- Tumor-Derived Factors Responsible for Dendritic Cell Dysfunction -- Tumor-Derived Exosomes as Dendritic Cell Modulators -- Signaling Pathways Mediating Dendritic Cell Dysfunction in Cancer -- A Role for STAT3 in Dendritic Cell Regulation by Tumor-Derived Factors -- Tumor-Associated Inflammation and Impact on Dendritic Cell Function -- Changes in Dendritic Cells in Cancer and Aging -- Stress, Immunity and Dendritic Cells in Cancer -- Cancer Therapy and Dendritic Cell Immunomodulation -- Role of Dendritic Cells in Tumor Escape -- Role of IDO in Dendritic Cell Differentiation and Function in Cancer -- Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis -- Protumorigenic Function of Dendritic Cells -- Dendritic Cell Maturation Versus Polarization in Tumor Escape -- Dendritic Cells in Cancer: Clinical Aspects -- Trafficking of Dendritic Cells in the Tumor Environment -- Dendritic Cells in Tumor-Draining Lymph Nodes -- Dendritic Cell Vaccines in Cancer: Obstaclesto Overcome -- How Best to Generate Dendritic Cells from Patients with Cancer and How Best to Use them for Immunotherapeutic Purposes -- Genetically Modified Dendritic Cells in Cancer Immunotherapy -- Dendritic Cell Tumors -- Future Directions in Dendritic Cell Research in Cancer.
520			_aSignificant features of cancer are suppression and redirection of the immune response, which allow for tumor development and growth in the previously immune competent host. Central to development of immune responses are dendritic cells, and unsurprisingly these cells are strongly impacted by tumors and factors derived from them, as well as by other conditions associated with tumor progression or cancer treatments. Further, as some of the frontline strategies for treatment of cancer involve immunotherapy with ex vivo cultured or in vivo modulated dendritic cells, it becomes imperative to understand how dendritic cells interact with and are affected by the tumor microenvironment. "Dendritic Cells in Cancer," edited by Michael R. Shurin and Russell D. Salter, presents thorough analyses of the complex biology of the tumor-dendritic cell relationship, and offers insights into how cancer treatments may benefit from furthering our understanding in this area.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aTOXICOLOGY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
700	1		_aShurin, Michael R. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387886107
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-88611-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c59386 _d59386