000			03698nam a22005415i 4500
001			978-0-387-89456-0
003			DE-He213
005			20251006084430.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387894560
020			_a99780387894560
024	7		_a10.1007/b135974 _2doi
082	0	4	_a616.9101 _223
100	1		_aRaney, Kevin D. _eeditor.
245	1	0	_aViral Genome Replication _h[electronic resource] / _cedited by Kevin D. Raney, Matthias Gotte, Craig E. Cameron.
264		1	_aBoston, MA : _bSpringer US, _c2009.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aGenome replication strategies -- Model of Picornavirus RNA Replication -- Coronavirus Genome Replication -- Flaviviruses -- Hepatitis C Virus Genome Replication -- Brome Mosaic Virus RNA Replication and Transcription -- Retroviruses -- Hepadnaviral Genomic Replication -- Rhabdoviruses -- Orthomyxovirus Genome Transcription and Replication -- Arenaviruses: Genome Replication Strategies -- Core-Associated Genome Replication Mechanisms of dsRNA Viruses -- Poxviruses -- Herpesvirus Genome Replication -- Host Factors Promoting Viral RNA Replication -- Host Factors that Restrict Retrovirus Replication -- Elements, factors and enzymes: Structure-function and mechanism -- T4 Phage Replisome -- Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase -- RNA Virus Polymerases -- Human Immunodeficiency Virus Reverse Transcriptase -- Viral Helicases -- Integrase: Structure, Function, and Mechanism -- Antivirals: Targets, mechanisms and resistance -- Viral DNA Polymerase Inhibitors -- Viral RNA Polymerase Inhibitors -- HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance -- Lethal Mutagenesis -- Clinical Implications of Reverse Transcriptase Inhibitor Resistance.
520			_aCurrently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.
650		0	_aMEDICINE.
650		0	_aHUMAN GENETICS.
650		0	_aIMMUNOLOGY.
650		0	_aMEDICAL VIROLOGY.
650		0	_aBIOCHEMISTRY.
650		0	_aCYTOLOGY.
650		0	_aMICROBIOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aVIROLOGY.
650	2	4	_aMICROBIOLOGY.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aHUMAN GENETICS.
700	1		_aGotte, Matthias. _eeditor.
700	1		_aCameron, Craig E. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387894256
856	4	0	_uhttp://dx.doi.org/10.1007/b135974 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c59442 _d59442