000			06046nam a22005055i 4500
001			978-0-387-92708-4
003			DE-He213
005			20251006084431.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387927084
020			_a99780387927084
024	7		_a10.1007/978-0-387-92708-4 _2doi
082	0	4	_a612.8 _223
100	1		_aUmemori, Hisashi. _eeditor.
245	1	4	_aThe Sticky Synapse _h[electronic resource] : _bCell Adhesion Molecules and Their Role in Synapse Formation and Maintenance / _cedited by Hisashi Umemori, Michael Hortsch.
264		1	_aNew York, NY : _bSpringer New York, _c2009.
300			_aXII, 456p. 46 illus., 21 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aA Short History of the Synapse - Golgi Versus Ramón y Cajal -- Cell Adhesion Molecules at the Drosophila Neuromuscular Junction -- Development of the Vertebrate Neuromuscular Junction -- Synapse Formation in the Mammalian Central Nervous System -- Developmental Axonal Pruning and Synaptic Plasticity -- Cell Adhesion Molecules in Synaptopathies -- The Cadherin Superfamily in Synapse Formation and Function -- Nectins and Nectin-Like Molecules in the Nervous System -- The Down Syndrome Cell Adhesion Molecule -- Molecular Basis of Lamina-Specific Synaptic Connections in the Retina: Sidekick Immunoglobulin Superfamily Molecules -- SYG/Nephrin/IrreC Family of Adhesion Proteins Mediate Asymmetric Cell-Cell Adhesion in Development -- L1-Type Cell Adhesion Molecules: Distinct Roles in Synaptic Targeting, Organization, and Function -- Cell Adhesion Molecules of the NCAM Family and Their Roles at Synapses -- MHC Class I Function at the Neuronal Synapse -- Pathfinding Molecules Branch Out: Semaphorin Family Members Regulate Synapse Development -- Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation -- Neurexins and Neuroligins: A Synaptic Code for Neuronal Wiring That Is Implicated in Autism -- Synaptic Adhesion-Like Molecules (SALMs) -- The Role of Integrins at Synapses -- Extracellular Matrix Molecules in Neuromuscular Junctions and Central Nervous System Synapses -- Gap Junctions as Electrical Synapses.
520			_aOver the last few years, a considerable number of different cell adhesion molecules (CAMs) have been identified that are imperative for synapse formation and maintenance. Recent research, however, has also revealed that many synaptic connections are highly dynamic and not as stable as initially thought. A delicate balance between adhesive and anti-adhesive events at the synapse suggests that CAM functions are highly regulated. Dr. Michael Hortsch and Dr. Hisashi Umemori's The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance presents the first comprehensive synopsis on how adhesive proteins contribute to synapse formation, function, and remodeling. Topics discussed range from general synaptic processes, such as neuromuscular junction and CNS synapse formation, to CAM-specific chapters on Cadherins, Ig-domain CAMs, Neuroligins, extracellular matrix molecules, Connexins and many others, and how these CAM families contribute specifically to synaptic functionality. The wide range of general and technical information offered in this book will appeal to students, researchers, and clinicians in the fields of molecular and cellular neuroscience, neurophysiology, and developmental neurobiology. . About the editors: Dr. Michael Hortsch holds a Diploma degree in Biochemistry from the Free University Berlin and a Ph.D. in Biology from the University of Heidelberg in Germany.While working at theWeizmann Institute in Israel, the European Molecular Biology Laboratory in Heidelberg, and at the University of California at Berkeley he has published on topics such as the mechanism of growth factor receptor activation, the transport of proteins across membranes, and the physiological roles of neuronal cell adhesion molecules during nervous system development. He has been a faculty member of the Department of Cell and Developmental Biology at the University of Michigan in Ann Arbor since 1991. Dr. Hortsch has served on scientific review panels for the National Institutes of Health, the National Science Foundation, and other agencies. Dr. Hisashi Umemori is a faculty member of the Molecular and Behavioral Neuroscience Institute and of the Department of Biological Chemistry at the University of Michigan Medical School. He worked with Dr. Tadashi Yamamoto at the Institute of Medical Sciences of the University of Tokyo and analyzed intracellular signaling mechanisms that are involved in myelination and in learning and memory.While working with Dr. Joshua R. Sanes atWashington University Medical School and at Harvard University, he identified synaptic organizing molecules that promote synapse formation during nervous system development. Currently, his laboratory is working to uncover the molecular mechanisms that govern the formation of functional neural circuits in the brain. Dr. Umemori has received various awards, including a Basil O'Connor Award and a Klingenstein Fellowship Award.
650		0	_aMEDICINE.
650		0	_aNEUROSCIENCES.
650		0	_aNEUROLOGY.
650		0	_aCYTOLOGY.
650		0	_aDEVELOPMENTAL BIOLOGY.
650		0	_aNEUROBIOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aNEUROSCIENCES.
650	2	4	_aNEUROBIOLOGY.
650	2	4	_aNEUROLOGY.
650	2	4	_aDEVELOPMENTAL BIOLOGY.
650	2	4	_aCELL BIOLOGY.
700	1		_aHortsch, Michael. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387927077
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-92708-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
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