000			03848nam a22005295i 4500
001			978-0-387-92808-1
003			DE-He213
005			20251006084431.0
007			cr nn 008mamaa
008			101013s2011 xxu| s |||| 0|eng d
020			_a9780387928081
020			_a99780387928081
024	7		_a10.1007/978-0-387-92808-1 _2doi
082	0	4	_a571.4 _223
100	1		_aWilliams, Mark C. _eeditor.
245	1	0	_aBiophysics of DNA-Protein Interactions _h[electronic resource] : _bFrom Single Molecules to Biological Systems / _cedited by Mark C. Williams, L. James Maher.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2011.
300			_aX, 350 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiological and Medical Physics, Biomedical Engineering, _x1618-7210
505	0		_aIntroduction -- Nonspecific DNA Binding: Searching DNA and Altering DNA Properties -- DNA Search Theory -- DNA Search, Hopping vs. Sliding -- SSB DNA Search -- HN-S Proteins or DNA Sliding Search -- Processivity Clamp -- DNA Bending Proteins -- Kinetics of DNA Binding and Bending by Proteins -- Modes of DNA Interaction by Architectural Proteins -- Complex Protein-DNA Interactions -- DNA Looping by Repressor Proteins -- NF-kappaB Transcription Factor Crystallography -- Replication Complex -- DNA Recombination Complexes -- DNA Binding by Alkyltransferase Repair Proteins -- DNA Polymerase Crystallography -- Polymerase Switching in Response to DNA Damage -- Single Molecule Studies on Chromatin -- Regulation of Chromosome Conformation in Cells -- Nucleosome Positioning Across Genomes.
520			_aThis book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.
650		0	_aPHYSICS.
650		0	_aMEDICINE.
650		0	_aBIOCHEMISTRY.
650		0	_aCYTOLOGY.
650		0	_aBIOMEDICAL ENGINEERING.
650	1	4	_aPHYSICS.
650	2	4	_aBIOPHYSICS AND BIOLOGICAL PHYSICS.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aBIOMEDICAL ENGINEERING.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aPROTEIN STRUCTURE.
700	1		_aMaher, L. James. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387928074
830		0	_aBiological and Medical Physics, Biomedical Engineering, _x1618-7210
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-92808-1 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-PHA
942			_2ddc _cER
999			_c59521 _d59521