000			03239nam a22004935i 4500
001			978-1-4020-3302-5
003			DE-He213
005			20251006084454.0
007			cr nn 008mamaa
008			100301s2005 ne | s |||| 0|eng d
020			_a9781402033025
020			_a99781402033025
024	7		_a10.1007/1-4020-3302-8 _2doi
082	0	4	_a614.5999 _223
100	1		_aSluyser, Mels. _eauthor.
245	1	0	_aApplication of Apoptosis to Cancer Treatment _h[electronic resource] / _cby Mels Sluyser.
264		1	_aDordrecht : _bSpringer Netherlands, _c2005.
300			_aVII, 370 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aDisfunction of the Apoptotic Pathway in Cancer Cells -- Calcium Signaling and Apoptosis Resistance of Cancer Cells -- Cell Clearance and Cancer -- Specific, Pro-Poptotic Cell-Signaling: Design of Novel, Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation of Cellular Apoptotic Events -- Targeting Oncogenes Which Regulate Apoptosis -- Targeting Cyclins to Cause Cancer Cell Apoptosis -- Apoptosis Induction By Tumor- Targeted Toxins -- Targeting Cell-Death Pathways in Multiple Myeloma: Therapeutic Implications -- Cephalostatin 1-Induced Apoptosis in Tumor Cells -- Hamlet; A Novel Tool to Identify Apoptotic Pathways in Tumor Cells -- Cancer Immunotherapy: On the Trail of a Cure? -- Histone Deacetylase Inhibitors as a Treatment of Trail-Resistant Cancers -- Basis of Cell Kill Following Clinical Radiotherapy -- Imaging of Apoptotic Cells in vivo -- Apoptosis-Inducing Anticancer Drugs in Clinical Trials.
520			_aNovel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world's leading experts in these fields.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aTOXICOLOGY.
650		0	_aPHARMACY.
650		0	_aLIFE SCIENCES.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aBIOMEDICINE GENERAL.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
650	2	4	_aPHARMACY.
650	2	4	_aLIFE SCIENCES, GENERAL.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402033032
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-3302-8 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c60406 _d60406