000 05124nam a22004935i 4500
001 978-1-4020-3414-5
003 DE-He213
005 20251006084455.0
007 cr nn 008mamaa
008 100301s2005 ne | s |||| 0|eng d
020 _a9781402034145
020 _a99781402034145
024 7 _a10.1007/1-4020-3414-8
_2doi
082 0 4 _a614.5999
_223
100 1 _aMeadows, Gary G.
_eeditor.
245 1 0 _aIntegration/Interaction of Oncologic Growth
_h[electronic resource] /
_cedited by Gary G. Meadows.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2005.
300 _aXIX, 454 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Growth and Progression ;
_v15
505 0 _aMicroenvironmental Effects on Tumour Progression and Metastasis -- Role of Microenvironment on Gene Expression, Angiogenesis and Microvascular Function in Tumors -- Imaging of Angiogenesis In Vivo with Fluorescent Proteins -- The Epigenetic Influence of the Tumor Microenvironment on Melanoma Plasticity -- Dynamics of Cell Adhesion Interactions during Melanoma Development -- Matrix Metalloproteinases: Mediators of Tumour-Host Cell Interactions -- Role of Brain Microenvironment in Brain Metastases -- Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone -- Interaction of Tumour with Host Stroma in Hepatocellular Carcinoma -- Dynamic Nature of Tumour-Host Interactions Within the Tumor Microenvironment -- Breast Cancer Progression: A "Vicious Cycle" of Pro-Malignancy Activities is Mediated by Inflammatory Cells, Chemokines and Cytokines -- Tumor and Host Endothelial Cell Selective Interactions and Modulation by Microenvironmental Chemokines: Tumor-Endothelial Cell Cross Talk Specificity -- The Role of Chemokine Receptors, in Particular CXCR4, in Lymphoma and Carcinoma Metastasis -- Energy Homeostasis and the Tumor/Host Interaction: The role of the Brain -- Anti-Angiogenic and Pro-Apoptotic Effects of Dietary Restriction in Experimental Brain Cancer: Role of Glucose and Ketone Bodies -- Dietary Restriction of Specific Amino Acids Modulates Tumor and Host Interactions -- Role of Tumour Microenvironment in Chemoresistance -- Integrin-Mediated Resistance to Chemotherapy-Induced Apoptosis in Cancer Cells -- Bone Metastasis Microenvironment Participates in the Development of Androgen Ablation Refractoriness and Chemotherapy Resistance of Prostate Cancer Cells Residing in the Skeleton: Clinical Implications -- Current and Future Therapeutic Targets of the Tumour-Host Microenvironment -- Bone Stromal Cells As Therapeutic Targets In Osseous Metastasis -- Organotropism of Lung Cancer Metastasis and its Molecular Targeted Therapy -- Maspin: A Novel Serine Protease Inhibitor -- Metastasis Suppressor Genes: A Brief Review of an Expanding Field -- Tumor-Host Interactions at the Metastatic Site: MKK4, Signal Transduction and the Stress Response.
520 _aThis book addresses the interactions and interrelationships between tumor and host that modulate progression and metastasis. A unique aspect of the book is that it highlights the tumor/host interactions as new targets for therapeutic intervention to control cancer. One promising approach is to target the host rather than the tumor itself, and several authors examine the potential for this novel tactic to oppress the manipulative cancer cell. The book examines the tumor and host relationship from multiple viewpoints: cellular and molecular events that occur during tumor-host cell interactions that control differentiation, cell proliferation, angiogenesis and vasculogenic mimicry, migration, apoptosis, invasion, metastasis. Other topics include the role of the immune response and chemokines/chemokine receptors, and the role of the brain and nutrients in tumor and host survival. Drug resistance limits cancer therapy, and the book emphasizes numerous novel and future therapeutic directions to sensitize drug resistant cells and other approaches that target the tumor and host microenvironment. This book will be of interest to cancer researchers who are interested in understanding metastasis, tumor and host interaction and interrelationships, and who have an interest in cancer control through development of novel targeting agents that impact these processes.
650 0 _aMEDICINE.
650 0 _aONCOLOGY.
650 0 _aIMMUNOLOGY.
650 0 _aLIFE SCIENCES.
650 1 4 _aBIOMEDICINE.
650 2 4 _aCANCER RESEARCH.
650 2 4 _aIMMUNOLOGY.
650 2 4 _aBIOMEDICINE GENERAL.
650 2 4 _aMOLECULAR MEDICINE.
650 2 4 _aLIFE SCIENCES, GENERAL.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402034138
830 0 _aCancer Growth and Progression ;
_v15
856 4 0 _uhttp://dx.doi.org/10.1007/1-4020-3414-8
_zVer el texto completo en las instalaciones del CICY
912 _aZDB-2-SBL
942 _2ddc
_cER
999 _c60449
_d60449