000			03063nam a22005175i 4500
001			978-1-4020-3462-6
003			DE-He213
005			20251006084456.0
007			cr nn 008mamaa
008			100301s2005 ne | s |||| 0|eng d
020			_a9781402034626
020			_a99781402034626
024	7		_a10.1007/1-4020-3462-8 _2doi
082	0	4	_a571.6 _223
100	1		_aManser, Ed. _eeditor.
245	1	0	_aRHO Family GTPases _h[electronic resource] / _cedited by Ed. Manser.
264		1	_aDordrecht : _bSpringer Netherlands, _c2005.
300			_aXIII, 296 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProteins and Cell Regulation ; _v3
505	0		_aThe Rho GTPases -- Evolution of the Human Rho GTPase Family -- Structural Analysis of Rho Protein Complexes -- Activation of GTPases by Dock180 Family of Proteins -- Rho GAPs - Regulators of Rho GTPases and More -- RhoA/C and the Actin Cytoskeleton -- Cdc42 and Rac Control of the Actin Cytoskeleton -- Regulation of Cell-Cell Adhesion by Rho Family GTPases -- Rho Proteins and Vesicle Trafficking -- The Prototype Rho-Associated Kinase PAK -- Genetic Analysis of Rho Protein Function in Mice -- Rho Proteins and Microtubules.
520			_aHumans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.
650		0	_aLIFE SCIENCES.
650		0	_aONCOLOGY.
650		0	_aMEDICINE.
650		0	_aBIOCHEMISTRY.
650		0	_aPROTEOMICS.
650		0	_aCYTOLOGY.
650	1	4	_aLIFE SCIENCES.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aPROTEOMICS.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aMOLECULAR MEDICINE.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402034619
830		0	_aProteins and Cell Regulation ; _v3
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-3462-8 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c60464 _d60464