000			03542nam a22005415i 4500
001			978-1-4020-4483-0
003			DE-He213
005			20251006084510.0
007			cr nn 008mamaa
008			100301s2006 ne | s |||| 0|eng d
020			_a9781402044830
020			_a99781402044830
024	7		_a10.1007/1-4020-4483-6 _2doi
082	0	4	_a616.33 _223
100	1		_aLendeckel, Uwe. _eeditor.
245	1	0	_aProteases in Gastrointestinal Tissues _h[electronic resource] / _cedited by Uwe Lendeckel, Nigel M. Hooper.
264		1	_aDordrecht : _bSpringer Netherlands, _c2006.
300			_aXVII, 343 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProteases in Biology and Disease, _x0952-0042 ; _v5
505	0		_aProtease-Activated Receptors in Gastrointestinal Function and Disease -- Matrix Metalloproteinases in Gastric Cancer -- Proteases in Helicobacter pylori-Mediated Diseases -- Proteases in Pancreatic Disease -- PAR in the Pathogenesis of Pain in Pancreatic Disease -- Importance of the Local Renin-Angiotensin System in Pancreatic Disease -- Hepatitis C Viral Proteases And Inhibitors -- Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis -- Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation -- MMPs and ADAMs in Inflammatory Bowel Disease -- Chemokines and Matrix Metalloproteinases in Colorectal Cancer -- Angiotensin-Converting Enzyme (ACE) in Gut Inflammation -- Intestinal Apical Protein Transport in Health and Disease.
520			_aThis book is unique for its comprehensive presentation of protease function in stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families, and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. This book is a valuable source for both clinicians and basic and clinical researchers interested in protease function and/or diseases in gastrointestinal tissues.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aTOXICOLOGY.
650		0	_aINTERNAL MEDICINE.
650		0	_aGASTROENTEROLOGY.
650		0	_aCLINICAL MEDICINE.
650	1	4	_aMEDICINE & PUBLIC HEALTH.
650	2	4	_aGASTROENTEROLOGY.
650	2	4	_aBIOMEDICINE GENERAL.
650	2	4	_aHEPATOLOGY.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aINTERNAL MEDICINE.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
700	1		_aHooper, Nigel M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402044823
830		0	_aProteases in Biology and Disease, _x0952-0042 ; _v5
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-4483-6 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SME
942			_2ddc _cER
999			_c60892 _d60892