000 04390nam a22005655i 4500
001 978-1-4020-5466-2
003 DE-He213
005 20251006084521.0
007 cr nn 008mamaa
008 100301s2007 ne | s |||| 0|eng d
020 _a9781402054662
020 _a99781402054662
024 7 _a10.1007/1-4020-5466-1
_2doi
082 0 4 _a616.9041
_223
100 1 _aKundu, Tapas K.
_eeditor.
245 1 0 _aChromatin and Disease
_h[electronic resource] /
_cedited by Tapas K. Kundu, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, P. Zwickl.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2007.
300 _aXIII, 458 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v41
505 0 _aChromatin Structure, Dynamics and Disease -- Structural Organization of Dynamic Chromatin -- ATP-dependent Chromatin Remodelling -- Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1 -- Histone Variant Nucleosomes -- Histone Variants and Complexes Involved in Their Exchange -- Histone Chaperones in Chromatin Dynamics -- Functions Of The Histone Chaperone Nucleolin In Diseases -- Chromatin as a Target for the DNA-Binding Anticancer Drugs -- Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease -- Reversible Acetylation Of Non Histone Proteins -- MARs and MARBPs -- Epigenetic Modifications of Chromatin: Implication in disease and therapeutics -- Aberrant Forms of Histone Acetyltransferases in Human Disease -- Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases -- Functions of Myst Family Histone Acetyltransferases and Their Link to Disease -- Role Of Histone Phosphorylation In Chromatin Dynamics And Its Implications in Diseases -- Regulation And Function Of H3K9 Methylation -- Histone Acetylation And Methylation -- Chromatin-Associated Regulation Of Hiv-1 Transcription -- Small Molecule Modulators In Epigenetics.
520 _aThe packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenerrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This work is the first endeavor to present different aspects encompassing the above theme.
650 0 _aMEDICINE.
650 0 _aMICROBIOLOGY.
650 0 _aMEDICAL VIROLOGY.
650 1 4 _aBIOMEDICINE.
650 2 4 _aMEDICAL MICROBIOLOGY.
650 2 4 _aVIROLOGY.
700 1 _aBittman, R.
_eeditor.
700 1 _aDasgupta, D.
_eeditor.
700 1 _aEngelhardt, H.
_eeditor.
700 1 _aFlohe, L.
_eeditor.
700 1 _aHerrmann, H.
_eeditor.
700 1 _aHolzenburg, A.
_eeditor.
700 1 _aNasheuer, H-P.
_eeditor.
700 1 _aRottem, S.
_eeditor.
700 1 _aWyss, M.
_eeditor.
700 1 _aZwickl, P.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402054655
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v41
856 4 0 _uhttp://dx.doi.org/10.1007/1-4020-5466-1
_zVer el texto completo en las instalaciones del CICY
912 _aZDB-2-SBL
942 _2ddc
_cER
999 _c61288
_d61288