000			03646nam a22004935i 4500
001			978-1-4020-5525-6
003			DE-He213
005			20251006084522.0
007			cr nn 008mamaa
008			100301s2008 ne | s |||| 0|eng d
020			_a9781402055256
020			_a99781402055256
024	7		_a10.1007/978-1-4020-5525-6 _2doi
082	0	4	_a571.4 _223
100	1		_aLeuchtag, H. Richard. _eeditor.
245	1	0	_aVoltage-Sensitive Ion Channels _h[electronic resource] : _bBiophysics of Molecular Excitability / _cedited by H. Richard Leuchtag.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aExploring Excitability -- Information In The Living Body -- Animal Electricity -- Electrophysiology Of The Axon -- Aspects Of Condensed Matter -- Ions In The Electric Field -- Ions Drift And Diffuse -- Multi-Ion And Transient Electrodiffusion -- Models Of Membrane Excitability -- Admittance To The Semicircle -- What's That Noise? -- Ion Channels, Proteins And Transitions -- Diversity And Structures Of Ion Channels -- Microscopic Models Of Channel Function -- Order From Disorder -- Polar Phases -- Delicate Phases And Their Transitions -- Propagation And Percolation In A Channel -- Screws And Helices -- Voltage-Induced Gating Of Ion Channels -- Branching Out.
520			_aVoltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book critically examines physically oriented approaches not covered in other ion-channel books. It looks at optical and thermal as well as electrical data, and at studies in the frequency domain as well as in the time domain. Rather than presenting the reader with only an option of mechanistic models at an inappropriate pseudo-macroscopic scale, it emphasizes concepts established in organic chemistry and condensed state physics. The book's approach to the understanding of these unique structures breaks with the unproven view of ion channels as structurally gated pores. Rather, it proposes gateless gating, in which the onset and cessation of avalanches of ions crossing the membrane is explained as a cooperative phenomenon in a system poised far from equilibrium. These events, called channel opening and closing, are initiated by an electrical depolarization, a mechanical stimulus or even a thermal fluctuation.
650		0	_aPHYSICS.
650		0	_aBIOCHEMISTRY.
650		0	_aANIMAL PHYSIOLOGY.
650		0	_aNEUROBIOLOGY.
650		0	_aSOFT CONDENSED MATTER.
650		0	_aBIOMEDICAL ENGINEERING.
650	1	4	_aPHYSICS.
650	2	4	_aBIOPHYSICS/BIOMEDICAL PHYSICS.
650	2	4	_aANIMAL PHYSIOLOGY.
650	2	4	_aSOFT MATTER, COMPLEX FLUIDS.
650	2	4	_aANIMAL BIOCHEMISTRY.
650	2	4	_aNEUROBIOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402055249
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-5525-6 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-PHA
942			_2ddc _cER
999			_c61315 _d61315