000			04645nam a22006615i 4500
001			978-1-4020-5688-8
003			DE-He213
005			20251006084524.0
007			cr nn 008mamaa
008			100301s2007 ne | s |||| 0|eng d
020			_a9781402056888
020			_a99781402056888
024	7		_a10.1007/1-4020-5688-5 _2doi
082	0	4	_a614.5999 _223
100	1		_aHarris, Randall E. _eeditor.
245	1	0	_aInflammation in the Pathogenesis of Chronic Diseases _h[electronic resource] : _bThe COX-2 Controversy / _cedited by Randall E. Harris, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, P. Zwickl.
264		1	_aDordrecht : _bSpringer Netherlands, _c2007.
300			_aXIII, 323 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSubcellular Biochemistry, _x0306-0225 ; _v42
505	0		_aHistorical Perspectives -- Anti-Inflammatory Drugs in the 21st Century -- Inflammatory Mechanisms of Pathogenesis -- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus -- Obesity, Inflammation, and Vascular Disease -- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer -- Role of COX-2 in Inflammatory and Degenerative Brain Diseases -- Inflammation and Cardiovascular Disease: The Coxib Controversy -- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors -- COX-2 Inhibitors And Cardiovascular Risk -- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib -- Cox-2 Blockade in Cancer Prevention and Therapy -- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade -- Strategies for Colon Cancer Prevention -- Inflammation and Neurodegenerative Disease -- NSAIDs for the Chemoprevention of Alzheimer's Disease -- Inflammation in parkinson's disease -- Nutrition, Inflammation and Chronic Disease -- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases -- Nutritional Intervention in Brain Aging.
520			_aThe authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specific chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer's disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aIMMUNOLOGY.
650		0	_aNEUROSCIENCES.
650		0	_aCARDIOLOGY.
650		0	_aNEUROLOGY.
650		0	_aPATHOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aPATHOLOGY.
650	2	4	_aCARDIOLOGY.
650	2	4	_aNEUROLOGY.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aNEUROSCIENCES.
700	1		_aBittman, R. _eeditor.
700	1		_aDasgupta, D. _eeditor.
700	1		_aEngelhardt, H. _eeditor.
700	1		_aFlohe, L. _eeditor.
700	1		_aHerrmann, H. _eeditor.
700	1		_aHolzenburg, A. _eeditor.
700	1		_aNasheuer, H-P. _eeditor.
700	1		_aRottem, S. _eeditor.
700	1		_aWyss, M. _eeditor.
700	1		_aZwickl, P. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402056871
830		0	_aSubcellular Biochemistry, _x0306-0225 ; _v42
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-5688-5 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c61391 _d61391