000			03150nam a22004935i 4500
001			978-1-4020-6650-4
003			DE-He213
005			20251006084536.0
007			cr nn 008mamaa
008			100301s2008 ne | s |||| 0|eng d
020			_a9781402066504
020			_a99781402066504
024	7		_a10.1007/978-1-4020-6650-4 _2doi
082	0	4	_a616.15 _223
100	1		_aMalone, P. Colm. _eauthor.
245	1	4	_aThe Aetiology of Deep Venous Thrombosis _h[electronic resource] : _bA Critical, Historical and Epistemological Survey / _cby P. Colm Malone, Paul S. Agutter.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_ato the Study of Deep Venous Thrombosis -- The Coagulation Cascade and the Consensus Model of DVT -- Hypercoagulability -- Historical Roots -- Coagulation and its Disorders: A History of Haematological Research -- Virchow and the Pathophysiological Tradition in the 19th Century -- The Pathophysiological Tradition after Virchow -- Interrupted Circulation: The 'Stasis' Hypothesis and the Significance of Venous Valves -- Underperfusion of Valve Pockets and the Initiation of DVT -- The Role of Endothelial Hypoxia in DVT -- The Valve Cusp Hypoxia Hypothesis -- Molecular Changes in the Hypoxic Endothelium -- Cadaver Clots or Agonal Thrombi?.
520			_aWhat we now call 'deep venous thrombosis' (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives - the haematological/biochemical - come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, they show that the current consensus model is conceptually flawed. Building on the work of William Harvey, John Hunter, Rudolf Virchow, Ludwig Aschoff and a number of pathologists in the mid-20th century, they offer a revised account of the aetiology of this condition. In the process they retrace and review the 160-year-old philosophical and methodological schism in biomedical research and, using DVT as an example, propose how this schism might be bridged to the benefit of both research and clinical practice.
650		0	_aMEDICINE.
650		0	_aMEDICINE _xPHILOSOPHY.
650		0	_aHEMATOLOGY.
650		0	_aPATHOLOGY.
650		0	_aVASCULAR SURGERY.
650	1	4	_aMEDICINE & PUBLIC HEALTH.
650	2	4	_aHEMATOLOGY.
650	2	4	_aPATHOLOGY.
650	2	4	_aHISTORY OF MEDICINE.
650	2	4	_aVASCULAR SURGERY.
650	2	4	_aPHILOSOPHY OF MEDICINE.
700	1		_aAgutter, Paul S. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402066498
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6650-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SME
942			_2ddc _cER
999			_c61800 _d61800