000			03415nam a22004695i 4500
001			978-1-4020-6704-4
003			DE-He213
005			20251006084536.0
007			cr nn 008mamaa
008			100301s2008 ne | s |||| 0|eng d
020			_a9781402067044
020			_a99781402067044
024	7		_a10.1007/978-1-4020-6704-4 _2doi
082	0	4	_a614.5999 _223
100	1		_aStavridis, John C. _eauthor.
245	1	0	_aOxidation: The Cornerstone of Carcinogenesis _h[electronic resource] : _bOxidation and Tobacco Smoke Carcinogenesis. A Relationship Between Cause and Effect / _cby John C. Stavridis.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aOxygen and Nitrogen Free Radicals -- Oxidative Stress -- Oxidative Damage of Genome DNA: Repair Mechanisms -- Mitochondria: Structure, Function and Relationship with Carcinogenesis -- Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants -- Cell Protection Mechanisms from Oxidation -- Role of DNA Adducts in Carcinogenesis -- Transmolecular Reactions of Genetic Toxicity: Alkylation and Methylation of DNA -- Toxicity and Carcinogenicity of Hydrocarbons -- Toxicity and Carcinogenicity of the Aromatic Hydrocarbons -- Toxicity and Carcinogenicity of Aldehydes -- Toxicity and Carcinogenicity of the Nitriles -- Toxicity and Carcinogenicity of the Eterocyclic Organic Compounds -- Toxicity and Carcinogenicity of Metals -- Oxidative Profile of Cigarette Smoke and Lung Cancer -- Smoking and Lung Cancer.
520			_aIn order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aHUMAN GENETICS.
650		0	_aTOXICOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aONCOLOGY.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402067037
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6704-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c61822 _d61822