000			03661nam a22004935i 4500
001			978-1-4020-6750-1
003			DE-He213
005			20251006084537.0
007			cr nn 008mamaa
008			100301s2008 ne | s |||| 0|eng d
020			_a9781402067501
020			_a99781402067501
024	7		_a10.1007/978-1-4020-6750-1 _2doi
082	0	4	_a614.5999 _223
100	1		_aYefenof, Eitan. _eeditor.
245	1	0	_aInnate and Adaptive Immunity in the Tumor Microenvironment _h[electronic resource] / _cedited by Eitan Yefenof.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_aXII,212pp. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aThe Tumor Microenvironment ; _v1
505	0		_aImmune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression -- Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor Cells -- Local Tumor Growth and Spontaneous Systemic T Cell Responses in Cancer Patients: A Paradox and Puzzle -- Insights into Mechanisms of Immune Resistance in the Tumor Microenvironment through Molecular Profiling -- Tumor Antigens as Modulators of the Tumor Microenvironment -- Tumor Cell Resistance to Apoptosis by Infi ltrating Cytotoxic Lymphocytes -- The Tumor Microenvironment as a Model for Tissue-Specific Rejection -- Functional Cytotoxicity of T Cells in the Tumor Microenvironment -- Natural Killer Cells at the Tumors Microenvironment -- Contribution of the Microenvironment to the Pathogenesis of EBV-Positive Hodgkin and Nasal NK/T-cell Lymphomas.
520			_aCancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aIMMUNOLOGY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aONCOLOGY.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aBIOMEDICINE GENERAL.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402067495
830		0	_aThe Tumor Microenvironment ; _v1
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6750-1 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c61843 _d61843