000			01427nam a2200229Ia 4500
003			MX-MdCICY
005			20251009160707.0
040			_cCICY
090			_aB-21859
245	1	0	_aFibrillarin from Archaea to human
490	0		_aBiol. Cell, 107, 159-174, 2015
500			_aArtículo
520	3		_aFibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
700	1	2	_aRodriguez‐Corona, U.
700	1	2	_aSobol, M.
700	1	2	_aRodriguez‐Zapata, L. C.
700	1	2	_aHozak, P.
700	1	2	_aCastano, E.
856	4	0	_uhttps://drive.google.com/file/d/1HeRyppVYTXc5-PcHXkK426CUEKAzFYIl/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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