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003			MX-MdCICY
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040			_cCICY
090			_aB-21862
245	1	0	_aProliferation, cancer, and aging-novel functions of the nucleolar methyltransferase fibrillarin?
490	0		_aCell Biol Int 42 (2018) 1463-1466, 2018
500			_aArtículo
520	3		_aFibrillarin is an essential nucleolar protein that catalyzes the 2′‐O‐methylation of ribosomal RNAs. Recently, experimental data have begun to accumulate that suggest that fibrillarin can influence various cellular processes, development of pathological processes, and even aging. The exact mechanism by which fibrillarin can influence these processes has not been found, but some experimental data indicate that up‐ or downregulation of fibrillarin can modify the ribosome structure and, thus, causе an alteration in relative efficiency with which various mRNAs are translated. Here, we discuss recent studies on the potential roles of fibrillarin in the regulation of cell proliferation, cancer progression, and aging.
650	1	4	_a20-O-METHYLATION
650	1	4	_aAGING
650	1	4	_aCANCER
650	1	4	_aFIBRILLARIN
650	1	4	_aPROLIFERATION
650	1	4	_aRIBOSOME HETEROGENEITY
700	1	2	_aShubina, M. Y.
700	1	2	_aMusinova, Y. R.
700	1	2	_aSheval, E. V.
856	4	0	_uhttps://drive.google.com/file/d/1mzPZRyzTLRrflggbcJFWRKyr83-eJhzE/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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