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003			MX-MdCICY
005			20251009160708.0
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090			_aB-21882
245	1	0	_aTIR signaling activates caspase-like immunity in bacteria
490	0		_aScience, 387(6733), 510-516, 2025
500			_aArtículo
520	3		_aCaspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5′-diphosphate-cyclo[N7:1′′]-ribose (N7-cADPR). This molecule specifically activates the bacterial caspase-like protease, which then indiscriminately degrades cellular proteins to halt phage replication. The TIR-caspase defense system, which we denote as type IV Thoeris, is abundant in bacteria and efficiently protects against phage propagation. Our study highlights the diversity of TIR-produced immune signaling molecules and demonstrates that cell death regulated by proteases of the caspase family is an ancient mechanism of innate immunity.
700	1	2	_aRousset, F.
700	1	2	_aOsterman, I.
700	1	2	_aScherf, T.
700	1	2	_aFalkovich, A. H.
700	1	2	_aLeavitt, A.
700	1	2	_aAmitai, G.
700	1	2	_aSorek, R.
856	4	0	_uhttps://drive.google.com/file/d/11sxSE5A98uTJoK2brLBXGJMy0IRS1sxU/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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