000			02093nam a2200313Ia 4500
003			MX-MdCICY
005			20251009160711.0
040			_cCICY
090			_aB-21967
245	1	0	_aPioneering NMR-based dereplication for identifying novel quinolone additives in personal care products: A new frontier in public health protection.
490	0		_aTalanta, 285, 127304, 2025.
500			_aArtículo
520	3		_aPersonal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with 13C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection.
650	1	4	_aPERSONAL CARE PRODUCTS
650	1	4	_aNMR DEREPLICATION
650	1	4	_aQUINOLONE ADDITIVES
650	1	4	_aILLEGAL ADDITIVES
650	1	4	_aMIXONAT
650	1	4	_aPUBLIC HEALTH PROTECTION
700	1	2	_aDu, X.
700	1	2	_aLin, X.
700	1	2	_aYuan, R.
700	1	2	_aYang, H.
700	1	2	_aLu, Y.
700	1	2	_aWu, X.
856	4	0	_uhttps://drive.google.com/file/d/1NW4Lq4OfsmOQFLl-Yze3W4zucxAZ9g2-/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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