000			01714nam a2200265Ia 4500
001			000008806
003			MX-MdCICY
005			20241009164544.0
008			081214c----2014ne-a###f#p---#000-0#eng-#
020			_a9783527332182 (hbk.)
040			_cCICY
082	0	4	_a615.19 _bN3 2014
245	1	0	_aNatural products in medicinal chemistry / _cedited by Stephen Hanessian
264	3	1	_aWeinheim, Ger. : _bWiley-VCH, _c2014
300			_axxi, 630 p. : _bil. ; _c24 cm.
490	0		_aMethods and principles in medicinal chemistry ; _v60
504			_aIncluye referencias bibliográficas e índice
520	3		_aThe inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 15 highly informative chapters. Using well-documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future directions in the field. The examples are carefully chosen so as to represent a wide range of chemical structures as well as therapeutic indications and include such "classical" cases as taxol and the vinca alkaloids as well the latest developments in protease inhibitors, antimicrobials, antifungals, antisense nucleosides, and epothilones.
650	1	4	_aCOMPUESTOS ORGANICOS _xSINTESIS
650	1	4	_aPRODUCTOS NATURALES
650	1	4	_aQUIMICA FARMACEUTICA
700	1	2	_aHanessian, Stephen, _eed.
856	4	0	_uhttps://www.cicy.mx/sitios/sib/doctoelectronico/8806.pdf _zVer tabla de contenido y/o resumen
942			_2ddc _cBK
999			_c8092 _d8092