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Isolation of mutants of unable to synthesize cadystin, small cadmium-binding peptides

Tipo de material: TextoTextoSeries ; BioChemical and Biophysical Research Communications , 151(1), p.32-39, 1988Trabajos contenidos:
  • Mutoh, N
  • Hayashi, Y
Tema(s): Recursos en línea: Resumen: synthesize small cadmium-binding peptides cadystin, structure of which is (-Glu-Cys)n-Gly, in response to cadmium. Mutants unable to synthesize cadystin were found in the mutants hypersensitive to cadmium. Some of them lack activity of either -glutamylcysteine synthetase (EC 6.3.2.2)or glutathione synthetase (EC 6.3.2.3), enzyme involved in glutathione biosynthesis. Some mutants have the same activity levels of these enzymes as wild type has. These results indicate that some steps of cadystin biosynthesis are catalyzed by the enzymes catalyzing glutathione biosynthesis.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-6713 (Browse shelf(Opens below)) Available

synthesize small cadmium-binding peptides cadystin, structure of which is (-Glu-Cys)n-Gly, in response to cadmium. Mutants unable to synthesize cadystin were found in the mutants hypersensitive to cadmium. Some of them lack activity of either -glutamylcysteine synthetase (EC 6.3.2.2)or glutathione synthetase (EC 6.3.2.3), enzyme involved in glutathione biosynthesis. Some mutants have the same activity levels of these enzymes as wild type has. These results indicate that some steps of cadystin biosynthesis are catalyzed by the enzymes catalyzing glutathione biosynthesis.

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