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What made sesquiterpene lactones reach cancer clinical trials?

Tipo de material: TextoTextoSeries ; Drug Discovery Today, 15(15-16), p.668-678, 2010Trabajos contenidos:
  • Ghantous, A
  • Gali-Muhtasib, H
  • Vuorela, H
  • Saliba, N.A
  • Darwiche, N
Recursos en línea: Resumen: Sesquiterpene lactones (SLs)are plant-derived compounds often used in traditional medicine against inflammation and cancer. This review focuses on the chemical and biological properties of SLs that lead to enhanced anticancer and anti-inflammatory effects. The chemical properties comprise alkylating center reactivity, lipophilicity, and molecular geometry and electronic features. SLs in clinical trials are artemisinin, thapsigargin and parthenolide and many of their synthetic derivatives. These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them head compounds in cancer clinical trials.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-12290 (Browse shelf(Opens below)) Available

Sesquiterpene lactones (SLs)are plant-derived compounds often used in traditional medicine against inflammation and cancer. This review focuses on the chemical and biological properties of SLs that lead to enhanced anticancer and anti-inflammatory effects. The chemical properties comprise alkylating center reactivity, lipophilicity, and molecular geometry and electronic features. SLs in clinical trials are artemisinin, thapsigargin and parthenolide and many of their synthetic derivatives. These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them head compounds in cancer clinical trials.

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