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Isolation of 4, 4?-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.

Tipo de material: TextoTextoSeries ; The Journal of antibiotics, 72(1), p.34, 2019Trabajos contenidos:
  • Chen, L
  • Li, Y. P
  • Li, X. X
  • Lu, Z. H
  • Zheng, Q. H
  • Liu, Q. Y
Tema(s): Recursos en línea: Resumen: 4,4?-bond secalonic acid D (4,4?-SAD)is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4?-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio. In vivo studies showed that 4,4?-SAD had antitumor efficacy in H22 cell xenograft model. Immunohistochemical analysis revealed that 4,4?-SAD could regulate Bax expression, which is a biomarker of tumor growth. In summary, 4,4?-SAD significantly inhibited tumor growth both in vivo and in vitro.
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4,4?-bond secalonic acid D (4,4?-SAD)is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4?-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio. In vivo studies showed that 4,4?-SAD had antitumor efficacy in H22 cell xenograft model. Immunohistochemical analysis revealed that 4,4?-SAD could regulate Bax expression, which is a biomarker of tumor growth. In summary, 4,4?-SAD significantly inhibited tumor growth both in vivo and in vitro.

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