Basics of Polymeric Scaffolds for Tissue Engineering
Basics of Polymeric Scaffolds for Tissue Engineering
- Journal of ASTM International, 3(9), p.1-10, 2006 .
This review article argues the case that there is a need for careful scaffold science for successful tissue engineering. Polymeric scaffolds should possess certain essential properties. However, these properties are not independent of each other and thus the development of a scaffold requires an optimization process. The article reviews several scaffold fabrication processes to highlight the complexity of the field. Issues related to porosity, permeability, and the need for adequate diffusion characteristics are discussed. Several previous studies on the effects of mixing in bioreactors are reviewed. Lastly, surface modification techniques are presented. In particular, recent work related to glow discharge gas plasma modification of biodegradable polymers is discussed.
SCAFFOLD SCIENCE
TISSUE ENGINEERING
FABRICATION TECHNIQUES
DIFFUSION, POROSITY
PERMEABILITY
SURFACE MODIFICATION
SURFACE PROPERTIES
BIODEGRADABLE
POLYMER
This review article argues the case that there is a need for careful scaffold science for successful tissue engineering. Polymeric scaffolds should possess certain essential properties. However, these properties are not independent of each other and thus the development of a scaffold requires an optimization process. The article reviews several scaffold fabrication processes to highlight the complexity of the field. Issues related to porosity, permeability, and the need for adequate diffusion characteristics are discussed. Several previous studies on the effects of mixing in bioreactors are reviewed. Lastly, surface modification techniques are presented. In particular, recent work related to glow discharge gas plasma modification of biodegradable polymers is discussed.
SCAFFOLD SCIENCE
TISSUE ENGINEERING
FABRICATION TECHNIQUES
DIFFUSION, POROSITY
PERMEABILITY
SURFACE MODIFICATION
SURFACE PROPERTIES
BIODEGRADABLE
POLYMER