In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase
In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase
- Antiviral Research, 19(3), p.207-217, 1992 .
Isoscutellarein (5,7,8,4'-tetrahydroxyflavone)from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 pM)the hydrolysis of sodium p-nitrophenyl-N-acetyl-a-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 #M. Negligible inhibitory activity was observed for mouse liver sialidase at a concentration of 79 pM. Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50
INFLUENZA VIRUS
SIALIDASE
NEURAMINIDASE
FLAVONOID
Isoscutellarein (5,7,8,4'-tetrahydroxyflavone)from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 pM)the hydrolysis of sodium p-nitrophenyl-N-acetyl-a-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 #M. Negligible inhibitory activity was observed for mouse liver sialidase at a concentration of 79 pM. Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50
INFLUENZA VIRUS
SIALIDASE
NEURAMINIDASE
FLAVONOID