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In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase

Tipo de material: TextoTextoSeries ; Antiviral Research, 19(3), p.207-217, 1992Trabajos contenidos:
  • Nagai, T
  • Miyaichi, Y
  • Tomimori, T
  • Suzuki, Y
  • Yamada, H
Tema(s): Recursos en línea: Resumen: Isoscutellarein (5,7,8,4'-tetrahydroxyflavone)from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 pM)the hydrolysis of sodium p-nitrophenyl-N-acetyl-a-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 #M. Negligible inhibitory activity was observed for mouse liver sialidase at a concentration of 79 pM. Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50
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Isoscutellarein (5,7,8,4'-tetrahydroxyflavone)from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 pM)the hydrolysis of sodium p-nitrophenyl-N-acetyl-a-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 #M. Negligible inhibitory activity was observed for mouse liver sialidase at a concentration of 79 pM. Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50

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