The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-function oxidase system
The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-function oxidase system
- Toxicofogy Letters, 5(6), p.369-374, 1980 .
A model system to detect the toxicity of pyrrolizidine alkaloids (PAS)was explored. Using the liver S-10 fraction, the effect of PAS on aniline hydroxylase and aminopyrine N-demethylase was examined. PAS were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.
A model system to detect the toxicity of pyrrolizidine alkaloids (PAS)was explored. Using the liver S-10 fraction, the effect of PAS on aniline hydroxylase and aminopyrine N-demethylase was examined. PAS were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.