Nanoparticle Formulation for Controlled Release of Capsaicin
Nanoparticle Formulation for Controlled Release of Capsaicin
- Journal of NanoScience and Nanotechnology, 11(5), p.4586-4591, 2011 .
Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25
CAPSAICIN
CONTROLLED RELEASE
PLLA
NANOPARTICLE
Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25
CAPSAICIN
CONTROLLED RELEASE
PLLA
NANOPARTICLE