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Nanoparticle Formulation for Controlled Release of Capsaicin

Tipo de material: TextoTextoSeries ; Journal of NanoScience and Nanotechnology, 11(5), p.4586-4591, 2011Trabajos contenidos:
  • Kim, S
  • Kim, J.C
  • Sul, D
  • Hwang, S.W
  • Lee, S.H
  • Kim, Y.H
  • Tae, G
Tema(s): Recursos en línea: Resumen: Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25
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Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25

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