Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius II. Isolation and Structure Determination
Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius II. Isolation and Structure Determination
- Natural Product Letters, 10(1), p.33-38, 1997 .
The structure of the potent nematicide omphalotin, isolated from the mycelia of the basidiomycete Omphalotus olearius, was determined by spectroscopic techniques. Omphalotin is a cyclic dodecapeptide consisting of 3 glycine, 5 valine, 3 isoleucine and 1 tryptophane, and 9 of the 12 a-nitrogens are methylated. HMBC and NOESY correlations between the N-methyl groups and the a-carbonda-hydrogens established the sequence of amino acids.
OMPHALOTUS OLEARIUS
OMPHALOTIN
CYCLOPEPTIDE
STRUCTURE DETERMINATION
The structure of the potent nematicide omphalotin, isolated from the mycelia of the basidiomycete Omphalotus olearius, was determined by spectroscopic techniques. Omphalotin is a cyclic dodecapeptide consisting of 3 glycine, 5 valine, 3 isoleucine and 1 tryptophane, and 9 of the 12 a-nitrogens are methylated. HMBC and NOESY correlations between the N-methyl groups and the a-carbonda-hydrogens established the sequence of amino acids.
OMPHALOTUS OLEARIUS
OMPHALOTIN
CYCLOPEPTIDE
STRUCTURE DETERMINATION