The chemistry and pharmacology of the genus dorstenia (moraceae)
The chemistry and pharmacology of the genus dorstenia (moraceae)
- Studies in Natural Products Chemistry, 29, p.761-805, 2003 .
The genus Dorstenia contains many plants that are used as anti-infection, anti-snakebite and anti-rheumatic remedies in the medicinal plant therapy of several countries in Africa, Central and South America. The genus is now recognized as a rich source of prenyl and geranyl-substituted coumarins, chalcones, flavanones, flavones and flavonols. Three naturally occurring styrenes were reported from D. barnimiana. The geranyl substituted furocoumarin, O-[3-(2,2-dimethyl-3-oxo-2H-furan-5-yl)butyl]bergaptol, has been found in many species.D. poinsettifolia furnished the unusual substituted 4-phenyldihydro furocoumarin. Prenylated and geranylated flavonoids have so far been reported only from African Dorstenia species. 5, 3'-Digeranyl-3,4,2',4'-tetrahydroxychalcone isolated from D. proropens, is the only example of a bis-geranylated chalcone in the literature. A part from 7,8- (2,2-dimethylpyrano-4'-methoxyflavanone (dorspoinsettifolin)from D. poinsettifolia and 3',4'- (2,2-dimethylpyrano-6-prenyl-7-hydroxyflavanone (dinklagin A)from D. dinklagei, all flavanone derivatives named dorsmanins A - J described here are from D. mannii. These dorsmanins appear to be derived from 6,8-diprenyl-5,7,3',4'-tetrahydroxyflavanone and a possible biosynthetic scheme for them is presented.D. Zenkeri yield a bichalcone derivative which is believed to arise from dorstenone another prenylated bichalcone isolated from D. barteri. The latter is probably formed via an enzymatic Diels-Alder reaction of 3'-prenyl-4,2'4'-trihydroxychalcone (isobavachalcone)and its dehydroderivative.D. psilurus provided all the triprenylated flavonoids found so far in Dorstenia and, of these, dorsilurin E is unique having ring B of the flavonoïd structure modified to a dienone. The pharmacological data on this genus are scanty. Extracts of D. multiradiata show antileishmanial activity. Extracts and /or compounds from other species show anti-inflammatory, analgesic, anti-oxidant and citotoxic activities. © 2003 Elsevier B.V. All rights reserved.
GENUS DORSTENIA (MORACEAE)
The genus Dorstenia contains many plants that are used as anti-infection, anti-snakebite and anti-rheumatic remedies in the medicinal plant therapy of several countries in Africa, Central and South America. The genus is now recognized as a rich source of prenyl and geranyl-substituted coumarins, chalcones, flavanones, flavones and flavonols. Three naturally occurring styrenes were reported from D. barnimiana. The geranyl substituted furocoumarin, O-[3-(2,2-dimethyl-3-oxo-2H-furan-5-yl)butyl]bergaptol, has been found in many species.D. poinsettifolia furnished the unusual substituted 4-phenyldihydro furocoumarin. Prenylated and geranylated flavonoids have so far been reported only from African Dorstenia species. 5, 3'-Digeranyl-3,4,2',4'-tetrahydroxychalcone isolated from D. proropens, is the only example of a bis-geranylated chalcone in the literature. A part from 7,8- (2,2-dimethylpyrano-4'-methoxyflavanone (dorspoinsettifolin)from D. poinsettifolia and 3',4'- (2,2-dimethylpyrano-6-prenyl-7-hydroxyflavanone (dinklagin A)from D. dinklagei, all flavanone derivatives named dorsmanins A - J described here are from D. mannii. These dorsmanins appear to be derived from 6,8-diprenyl-5,7,3',4'-tetrahydroxyflavanone and a possible biosynthetic scheme for them is presented.D. Zenkeri yield a bichalcone derivative which is believed to arise from dorstenone another prenylated bichalcone isolated from D. barteri. The latter is probably formed via an enzymatic Diels-Alder reaction of 3'-prenyl-4,2'4'-trihydroxychalcone (isobavachalcone)and its dehydroderivative.D. psilurus provided all the triprenylated flavonoids found so far in Dorstenia and, of these, dorsilurin E is unique having ring B of the flavonoïd structure modified to a dienone. The pharmacological data on this genus are scanty. Extracts of D. multiradiata show antileishmanial activity. Extracts and /or compounds from other species show anti-inflammatory, analgesic, anti-oxidant and citotoxic activities. © 2003 Elsevier B.V. All rights reserved.
GENUS DORSTENIA (MORACEAE)