The chemistry and pharmacology of the genus dorstenia (moraceae) (Record no. 50713)

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control field 20250625160153.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16543
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Title The chemistry and pharmacology of the genus dorstenia (moraceae)
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Volume/sequential designation Studies in Natural Products Chemistry, 29, p.761-805, 2003
520 3# - SUMMARY, ETC.
Summary, etc. The genus Dorstenia contains many plants that are used as anti-infection, anti-snakebite and anti-rheumatic remedies in the medicinal plant therapy of several countries in Africa, Central and South America. The genus is now recognized as a rich source of prenyl and geranyl-substituted coumarins, chalcones, flavanones, flavones and flavonols. Three naturally occurring styrenes were reported from D. barnimiana. The geranyl substituted furocoumarin, O-[3-(2,2-dimethyl-3-oxo-2H-furan-5-yl)butyl]bergaptol, has been found in many species.D. poinsettifolia furnished the unusual substituted 4-phenyldihydro furocoumarin. Prenylated and geranylated flavonoids have so far been reported only from African Dorstenia species. 5, 3'-Digeranyl-3,4,2',4'-tetrahydroxychalcone isolated from D. proropens, is the only example of a bis-geranylated chalcone in the literature. A part from 7,8- (2,2-dimethylpyrano-4'-methoxyflavanone (dorspoinsettifolin)from D. poinsettifolia and 3',4'- (2,2-dimethylpyrano-6-prenyl-7-hydroxyflavanone (dinklagin A)from D. dinklagei, all flavanone derivatives named dorsmanins A - J described here are from D. mannii. These dorsmanins appear to be derived from 6,8-diprenyl-5,7,3',4'-tetrahydroxyflavanone and a possible biosynthetic scheme for them is presented.D. Zenkeri yield a bichalcone derivative which is believed to arise from dorstenone another prenylated bichalcone isolated from D. barteri. The latter is probably formed via an enzymatic Diels-Alder reaction of 3'-prenyl-4,2'4'-trihydroxychalcone (isobavachalcone)and its dehydroderivative.D. psilurus provided all the triprenylated flavonoids found so far in Dorstenia and, of these, dorsilurin E is unique having ring B of the flavonoïd structure modified to a dienone. The pharmacological data on this genus are scanty. Extracts of D. multiradiata show antileishmanial activity. Extracts and /or compounds from other species show anti-inflammatory, analgesic, anti-oxidant and citotoxic activities. © 2003 Elsevier B.V. All rights reserved.
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element GENUS DORSTENIA (MORACEAE)
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ngadjui, B.T.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Abegaz, B.M.
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16543 25.06.2025 25.06.2025 Documentos solicitados