Post-translational quantitation by SRM/MRM: applications in cardiology
Post-translational quantitation by SRM/MRM: applications in cardiology
- Expert Review of proteomics, 15(6), p.477-502, 2018 .
Post-translational modifications (PTMs)have an important role in the regulation of protein function, localization, and interaction with other molecules. PTMs apply a dynamic control of proteins in both physiological and pathological conditions. The study of disease-specific PTMs allows identifying potential biomarkers and developing effective drugs. Enrichment techniques combined with high-resolution mass spectrometry (MS)/MS analysis provide attractive results on PTM characterization. Selected reaction monitoring/multiple reaction monitoring (SRM/MRM)is a powerful targeted assay for the quantitation and validation of PTMs in complex biological samples.
BIOMARKERS
CARDIOVASCULAR PROTEOMICS
MASS SPECTROMETRY
MULTIPLE REACTION MONITORING
POST-TRANSLATIONAL MODIFICATIONS
PROTEIN FUNCTION
SELECTED REACTION MONITORING
TARGETED PROTEOMICS
Post-translational modifications (PTMs)have an important role in the regulation of protein function, localization, and interaction with other molecules. PTMs apply a dynamic control of proteins in both physiological and pathological conditions. The study of disease-specific PTMs allows identifying potential biomarkers and developing effective drugs. Enrichment techniques combined with high-resolution mass spectrometry (MS)/MS analysis provide attractive results on PTM characterization. Selected reaction monitoring/multiple reaction monitoring (SRM/MRM)is a powerful targeted assay for the quantitation and validation of PTMs in complex biological samples.
BIOMARKERS
CARDIOVASCULAR PROTEOMICS
MASS SPECTROMETRY
MULTIPLE REACTION MONITORING
POST-TRANSLATIONAL MODIFICATIONS
PROTEIN FUNCTION
SELECTED REACTION MONITORING
TARGETED PROTEOMICS