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Post-translational quantitation by SRM/MRM: applications in cardiology

Tipo de material: TextoTextoSeries ; Expert Review of proteomics, 15(6), p.477-502, 2018Trabajos contenidos:
  • Gianazza, E
  • Banfi, C
Tema(s): Recursos en línea: Resumen: Post-translational modifications (PTMs)have an important role in the regulation of protein function, localization, and interaction with other molecules. PTMs apply a dynamic control of proteins in both physiological and pathological conditions. The study of disease-specific PTMs allows identifying potential biomarkers and developing effective drugs. Enrichment techniques combined with high-resolution mass spectrometry (MS)/MS analysis provide attractive results on PTM characterization. Selected reaction monitoring/multiple reaction monitoring (SRM/MRM)is a powerful targeted assay for the quantitation and validation of PTMs in complex biological samples.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-17368 (Browse shelf(Opens below)) Available

Post-translational modifications (PTMs)have an important role in the regulation of protein function, localization, and interaction with other molecules. PTMs apply a dynamic control of proteins in both physiological and pathological conditions. The study of disease-specific PTMs allows identifying potential biomarkers and developing effective drugs. Enrichment techniques combined with high-resolution mass spectrometry (MS)/MS analysis provide attractive results on PTM characterization. Selected reaction monitoring/multiple reaction monitoring (SRM/MRM)is a powerful targeted assay for the quantitation and validation of PTMs in complex biological samples.

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