Skin tissue engineering-in vivo and in vitro applications.
Skin tissue engineering-in vivo and in vitro applications.
- Advanced Drug Delivery Reviews, 63(4-5), p.352-366, 2011 .
Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.
TISSUE ENGINEERING
EXTRACELLULAR MATRIX
SKIN
IN VITRO MODELS
KERATINOCYTES
MELANOCYTES
Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.
TISSUE ENGINEERING
EXTRACELLULAR MATRIX
SKIN
IN VITRO MODELS
KERATINOCYTES
MELANOCYTES