MARC details
| 000 -LEADER |
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| fixed length control field |
02170nam a2200277Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20250625122510.0 |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
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| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
B-6085 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT |
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| Title |
The Isolation of FOS-1, a Gene Encoding a Putative Two-Component Histidine Kinase from Aspergillus fumigatus |
| 490 0# - SERIES STATEMENT |
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| Volume/sequential designation |
Fungal Genetics and Biology , 31(1), p.55-67, 2000 |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc. |
In fungi, two-component histidine kinases are involved in response mechanisms to extracellular changes in osmolarity, resistance to dicarboximide fungicides, and cell-wall assembly. In the human opportunistic fungus, Candida albicans, each of the three histidine kinases plays a role in virulence. Here, we identify, for the first time, a gene, FOS-1, from the human pathogenic fungus Aspergillus fumigatus that predicts a protein with homology to two-component histidine kinases. The predicted FOS-1 protein is highly homologous to bacterial and other fungal histidine kinases in several functional domains, but is divergent at the amino- and carboxy-termini. A mutant lacking the FOS-1 locus, ?FOS-1, did not exhibit a detectable defect in either hyphal growth or morphology when grown on solid or liquid medium. However, in liquid medium, conidiophore development of the ?FOS-1 mutant was delayed. Compared to wild type, the ?FOS-1 strain was neither osmotically sensitive nor sensitive or resistant to a number of nondicarboximide antifungal drugs, but was highly resistant to dicarboximide fungicides and resistant to novozym 234, suggesting that FOS-1p may play a role in the regulation of cell-wall assembly. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
ASPERGILLUS FUMIGATUS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
TWO-COMPONENT HISTIDINE KINASE |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
DICARBOXIMIDE ANTIFUNGAL COMPOUNDS |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
FOS-1 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
CELL-WALL ASSEMBLY |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Potta, G.B. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Millera, T.K. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Bartletta, J.A. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Palasb, J.S. |
| 700 12 - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Selitrennikoff, C.P. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1U5UkZCRAIZhdi1N5kw7TdjfRP6l_WI_s/view?usp=drivesdk">https://drive.google.com/file/d/1U5UkZCRAIZhdi1N5kw7TdjfRP6l_WI_s/view?usp=drivesdk</a> |
| Public note |
Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Clasificación local |
| Koha item type |
Documentos solicitados |
