Synthesis and anti-tumor evaluation of new trisulfide derivatives (Record no. 44679)

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control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625140631.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-10446
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Title Synthesis and anti-tumor evaluation of new trisulfide derivatives
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Volume/sequential designation Bioorganic & Medicinal Chemistry Letters, 16(18), p.4826-4829, 2006
520 3# - SUMMARY, ETC.
Summary, etc. New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4)to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
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Personal name Haoyun An
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Personal name Zhu, J.
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Personal name Wang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Xu, X.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1fdRAxV2AzLjYfO_3eRKb1wV5A-_cOWXd/view?usp=drivesdk">https://drive.google.com/file/d/1fdRAxV2AzLjYfO_3eRKb1wV5A-_cOWXd/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-10446 25.06.2025 25.06.2025 Documentos solicitados