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Synthesis and anti-tumor evaluation of new trisulfide derivatives

Tipo de material: TextoTextoSeries ; Bioorganic & Medicinal Chemistry Letters, 16(18), p.4826-4829, 2006Trabajos contenidos:
  • Haoyun An
  • Zhu, J
  • Wang, X
  • Xu, X
Recursos en línea: Resumen: New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4)to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-10446 (Browse shelf(Opens below)) Available

New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4)to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.

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