Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome (Record no. 46453)

MARC details
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fixed length control field 02107nam a2200325Ia 4500
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control field MX-MdCICY
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control field 20250625140705.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-12242
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Title Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome
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Volume/sequential designation The EMBO Journal, 29, p.3496-3506, 2010
520 3# - SUMMARY, ETC.
Summary, etc. In diverse eukaryotes, constitutively silent sequences, such as transposons and repeats, are marked by methylation at histone H3 lysine 9 (H3K9me). Although selective H3K9me is critical for maintaining genome integrity, mechanisms to exclude H3K9me from active genes remain largely unexplored. Here, we show in Arabidopsis that the exclusion depends on a histone demethylase gene, IBM1 (increase in BONSAI methylation). Loss-of-function ibm1 mutation results in ectopic H3K9me and non-CG methylation in thousands of genes. The ibm1-induced genic H3K9me depends on both histone methylase KYP/SUVH4 and DNA methylase CMT3, suggesting interdependence of two epigenetic marks-H3K9me and non-CG methylation. notably, IBM1 enhances loss of H3K9me in transcriptionally de-repressed sequences. Furthermore, disruption of transcription in genes induces ectopic non-CG methylation, which mimics the loss of IBM1 function. We propose that active chromatin is stabilized by an autocatalytic loop of transcription and H3K9 demethylation. This process counteracts a similarly autocatalytic accumulation of silent epigenetic marks, H3K9me and non-CG methylation.
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Topical term or geographic name entry element CHROMATIN
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DNA METHYLATION
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Topical term or geographic name entry element HISTONE DEMETHYLASE
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Topical term or geographic name entry element IBM1
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Topical term or geographic name entry element TRANSPOSON
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Inagaki, S.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Miura-Kamio, A.
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Personal name Nakamura, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lu, F.
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Personal name Cui, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Cao, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kimura, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kimura, H.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Kakutani, T.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1zIs9SfQAtE4UpkuX9D_pcSskcGX3AUYI/view?usp=drivesdk">https://drive.google.com/file/d/1zIs9SfQAtE4UpkuX9D_pcSskcGX3AUYI/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-12242 25.06.2025 25.06.2025 Documentos solicitados