A nuclear 'fossil' of the mitochondrial d-loop and the origin of modern humans (Record no. 50577)

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fixed length control field 02195nam a2200373Ia 4500
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control field MX-MdCICY
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control field 20250625160150.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16403
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Title A nuclear 'fossil' of the mitochondrial d-loop and the origin of modern humans
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Volume/sequential designation Nature, 378(6556), p.489-492, 1995
520 3# - SUMMARY, ETC.
Summary, etc. Mammalian mitochondria! DNA sequences evolve more rapidly than nuclear sequences1. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple substitutions obliterate the phylogenetic information2. However, mitochondrial DNA sequences are frequently inserted into the nuclear genome3, where they presumably evolve as nuclear pseudogene sequences and therefore more slowly than their mitochondria! counterparts. Such sequences thus represent molecular 'fossils' that could shed light on the evolution of the mitochondrial genome and could be used as outgroups in situations where no appropriate outgroup species exist. Here we show that human chromosome 11 carries a recent integration of the mitochondrial control region that can be used to gain further insight into the origin of the human mitochondrial gene pool. © 1995 Nature Publishing Group. All rights reserved.
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Topical term or geographic name entry element ANIMAL
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Topical term or geographic name entry element BASE SEQUENCE
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Topical term or geographic name entry element CHROMOSOMES, HUMAN, PAIR 11
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Topical term or geographic name entry element DNA, MITOCHONDRIAL
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Topical term or geographic name entry element EVOLUTION, MOLECULAR
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Topical term or geographic name entry element HOMINIDAE
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Topical term or geographic name entry element HUMAN
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Topical term or geographic name entry element MALE
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Topical term or geographic name entry element MOLECULAR SEQUENCE DATA
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Topical term or geographic name entry element PAN TROGLODYTES
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Topical term or geographic name entry element POLYMERASE CHAIN REACTION
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Topical term or geographic name entry element PSEUDOGENES
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Topical term or geographic name entry element RECOMBINATION, GENETIC
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Topical term or geographic name entry element SPERM HEAD
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Personal name Zischler, H.
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Personal name Geisert, H.
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Personal name Von Haeseler, A.
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Personal name Pääbo, S.
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Uniform Resource Identifier <a href="https://drive.google.com/file/d/1RouaWR15e7Tip1-Gs2iYkTtix42Ti8bp/view?usp=drivesdk">https://drive.google.com/file/d/1RouaWR15e7Tip1-Gs2iYkTtix42Ti8bp/view?usp=drivesdk</a>
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Source of classification or shelving scheme Clasificación local
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16403 25.06.2025 25.06.2025 Documentos solicitados