Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator (Record no. 50827)

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control field MX-MdCICY
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control field 20250625160155.0
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Transcribing agency CICY
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Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-16657
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Title Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator
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Volume/sequential designation Nat Biotechnol., 35(7), p.647-652, 2017
520 3# - SUMMARY, ETC.
Summary, etc. Lipid production in the industrial microalga Nannochloropsis gaditana exceeds that of model algal species and can be maximized by nutrient starvation in batch culture. However, starvation halts growth, thereby decreasing productivity. Efforts to engineer N. gaditana strains that can accumulate biomass and overproduce lipids have previously met with little success. We identified 20 transcription factors as putative negative regulators of lipid production by using RNA-seq analysis of N. gaditana during nitrogen deprivation. Application of a CRISPR-Cas9 reverse-genetics pipeline enabled insertional mutagenesis of 18 of these 20 transcription factors. Knocking out a homolog of fungal Zn(II)2Cys6-encoding genes improved partitioning of total carbon to lipids from 20
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Personal name Ajjawi I
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Personal name Verruto J
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Personal name Aqui M
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Personal name Soriaga Lb
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Personal name Coppersmith J
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Personal name Kwok K
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Personal name Peach L
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Personal name Peach L
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Personal name Kalb R
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Personal name Xu W
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Personal name Carlson Tj
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Personal name Francis K
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Personal name Konigsfeld K
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Personal name Bartalis J
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Personal name Schultz A
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Personal name Lambert W
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Personal name Schwartz As
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Personal name Brown R
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Personal name Moellering Er
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/177Tkzk9POWsmWmuyQaWcnyH1GlABdf5m/view?usp=drivesdk">https://drive.google.com/file/d/177Tkzk9POWsmWmuyQaWcnyH1GlABdf5m/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-16657 25.06.2025 25.06.2025 Documentos solicitados