Precision genome engineering through adenine base editing in plants (Record no. 51258)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01642nam a2200253Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-MdCICY |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625160204.0 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CICY |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | B-17095 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - TITLE STATEMENT | |
| Title | Precision genome engineering through adenine base editing in plants |
| 490 0# - SERIES STATEMENT | |
| Volume/sequential designation | Nature Plants, 4, p.427-431, 2018 |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The recent development of adenine base editors (ABEs)has enabled efficient and precise A-to-G base conversions in higher eukaryotic cells. Here, we show that plant-compatible ABE systems can be successfully applied to protoplasts of Arabidopsis thaliana and Brassica napus through transient transfection, and to individual plants through Agrobacterium-mediated transformation to obtain organisms with desired phenotypes. Targeted, precise A-to-G substitutions generated a single amino acid change in the FT protein or mis-splicing of the PDS3 RNA transcript, and we could thereby obtain transgenic plants with late-flowering and albino phenotypes, respectively. Our results provide 'proof of concept' for in planta ABE applications that can lead to induced neo-functionalization or altered mRNA splicing, opening up new avenues for plant genome engineering and biotechnology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GENOME ENGINEERING |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kang, B. C. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yun, J. Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kim, S. T. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shin, Y. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ryu, J. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Choi, M. |
| 700 12 - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kim, J. S. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/1HCKqQb1qkb_EqsQQWmrXeC5zKDGyWCth/view?usp=drivesdk">https://drive.google.com/file/d/1HCKqQb1qkb_EqsQQWmrXeC5zKDGyWCth/view?usp=drivesdk</a> |
| Public note | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Clasificación local |
| Koha item type | Documentos solicitados |
| Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clasificación local | Ref1 | CICY | CICY | Documento préstamo interbibliotecario | 25.06.2025 | B-17095 | 25.06.2025 | 25.06.2025 | Documentos solicitados |