Safrole: its metabolism, carcinogenicity and interactions with cytochrome p-450 (Record no. 52895)

MARC details
000 -LEADER
fixed length control field 01478nam a2200193Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162418.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-18749
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250602s9999 xx |||||s2 |||| ||und|d
245 10 - TITLE STATEMENT
Title Safrole: its metabolism, carcinogenicity and interactions with cytochrome p-450
490 0# - SERIES STATEMENT
Volume/sequential designation Food Cosmet, Toxicol., p.657-666, 1981
520 3# - SUMMARY, ETC.
Summary, etc. A review of studies on safrole metabolism shows that the compound gives rise to a large number of metabolites by two major pathways, oxidation of the ally1 side chain and oxidation of the methylenedioxy group with subsequent cleavage to form a catechol. The mechanism by which safrole exerts the weak hepatocarcinogenicity that has been demonstrated in rats and mice is considered on the basis of published work and recent studies by the authors. Metabolic conversion of the ally1 group gives rise to intermediates capable of covalent binding with DNA and protein, and recent findings are compatible with conversion of the methylenedioxy group to a carbene, which forms ligand complexes with the haem moiety of cytochromes P-450 and P-448. It is suggested that while the ally1 group is responsible for the mutagenic potentia
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Ioannides, C.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Delaforge, M.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Park, D. V.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/154nxOivZneHVnE0emVkCxu2vjZRfZKA6/view?usp=drivesdk">https://drive.google.com/file/d/154nxOivZneHVnE0emVkCxu2vjZRfZKA6/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
Holdings
Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-18749 25.06.2025 25.06.2025 Documentos solicitados